An unexpected role for p53 in regulating cancer cell–intrinsic PD-1 by acetylation
Cao, Z., Kon, N., Liu, Y. et al. An unexpected role for p53 in regulating cancer cell–intrinsic PD-1 by acetylation. Sci Adv. (2021). DOI: 10.1126/sciadv.abf4148
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Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer
Wang, S., Qu, Y., Xia, P. et al. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Res. (2020). https://doi.org/10.1038/s41422-020-0312-y
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Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants
Nie, J., Xie, J., Liu, S. Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants. Cell Discov. (2021). https://doi.org/10.1038/s41421-021-00292-z
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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
Park, J.-J., Thi, E.P., Carpio, V.H. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. (2021). https://doi.org/10.1038/s41467-021-21410-1
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Targeting macrophage checkpoint inhibitor SIRPα for anticancer therapy
Liu, J., Xavy, S., Mihardja, S. et al. Targeting macrophage checkpoint inhibitor SIRPα for anticancer therapy. JCI Insight. (2020). https://doi.org/10.1172/jci.insight.134728
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Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist
Upadhyaya, P., Lahdenranta, J., Hurov, K. et al. Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist. J Immunother Cancer. (2021). http://dx.doi.org/10.1136/jitc-2020-001762
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B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes
You, G., Lee, Y., Kang, Y.-W. et al. B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes. Sci Adv. (2021). DOI: 10.1126/sciadv.aax3160
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Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice
Peng, J., Liu, Y., Umpierre, A.D. et al. Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice. Mol Brain. (2019). https://doi.org/10.1186/s13041-019-0492-x
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NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival
Grun, D., Adhikary, G., Eckert, R.L. NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival. Oncogene. (2018). https://doi.org/10.1038/s41388-018-0290-4
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Discovery of the Oncogenic Parp1, a Target of bcr-abl and a Potential Therapeutic, in mir-181a/PPFIA1 Signaling Pathway
Gu, C., Liu, Y., Yin, Z. Discovery of the Oncogenic Parp1, a Target of bcr-abl and a Potential Therapeutic, in mir-181a/PPFIA1 Signaling Pathway. Mol Ther Nucleic Acids. (2019). https://doi.org/10.1016/j.omtn.2019.01.015
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