G protein-coupled receptors (GPCRs) play an integral role in transmitting cellular growth and migration signals in a variety of biological contexts. Alterations in GPCR signaling are associated with immune dysregulation and cancer progression, making GPCRs attractive drug targets. However, the complex biochemical structure and shared homology among family members has made targeting GPCRs difficult. Biocytogen has engineered several strains of humanized GPCR mice to test human GPCR drug candidates. Use of our humanized GPCR models allows for comprehensive safety, dosing, and efficacy testing of your therapeutic candidates prior to clinical development.
Humanized GPCR Mice
| Product | Product No | Background |
|---|---|---|
| B-hA2AR mice | 110120 | C57BL/6J |
| B-hC5AR1 Mice | 110078 | C57BL/6J |
| B-hCALCRL mice | 110115 | C57BL/6J |
| B-hCB1 mice | 110943 | C57BL/6N |
| B-hCCL20 mice | 110854 | C57BL/6N |
| B-hCCR2 mice | 110097 | C57BL/6N |
| B-hCCR3 mice | 111401 | C57BL/6N |
| B-hCCR4 mice | 110098 | C57BL/6J |
| B-hCCR5 mice | 110099 | C57BL/6J |
| B-hCCR6 mice | 110853 | C57BL/6N |
| B-hCCR7 mice | 111557 | C57BL/6N |
| B-hCCR8 mice | 110096 | C57BL/6J |
| B-hCCR9 mice | 110972 | C57BL/6N |
| B-hCGRP mice | 110118 | C57BL/6N |
| B-hCLDN6 mice | 111086 | C57BL/6N |
| B-hCRTH2 mice | ||
| B-hCRTH2 mice plus | 112547 | C57BL/6N |
| B-hCX3CR1 mice | 110101 | C57BL/6J |
| B-hCXCR2 mice | 110816 | C57BL/6 |
| B-hCXCR3 mice | 110969 | C57BL/6N |
| B-hCXCR4 mice | 110100 | C57BL/6J |
| B-hCXCR5 mice | 110970 | C57BL/6N |
| B-hETAR mice | 110108 | C57BL/6J |
| B-hGCGR mice | 110105 | C57BL/6J |
| B-hGLP1R mice | 170164 | C57BL/6J |
| B-hGPRC5D mice | 111240 | C57BL/6N |
| Tara jupiter mice | 383002 | Y |
