Dawson Quote

My laboratory over the years has made 13 gene targeted mice with Biocytogen. Many of the gene-targeted mice were challenging projects, but Biocytogen was able to deliver on each project in a timely and professional manner. We use Biocytogen for all our knockout and knockin mice projects.”

Ted M. Dawson, MD, PhD

John Hopkins University

Dawson Quote

Our team has engaged Biocytogen in numerous
projects in making site specific knockin mouse
models since 2020. We are very satisfied with their
professional design and scientific communication,
model quality and delivery timeline. The delivered
models indeed help our group's research and
discoveries. We look forward to working with
Biocytogen and Dan's team in the years to come.”

Omer H. Yilmaz, MD, PhD

Koch Institute for Integrative Cancer Research at MIT,
Massachusetts General Hospital and Harvard Medical School

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RenBiologics Achievements & Milestones

Therapeutic Antibody Agreements
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Target-nominated RenMice Licensing Projects
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Fully-human Antibody Sequences
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BioMice Achievements & Milestone

Custom models provided
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Off-the-shelf Products
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Drug evaluation projects completed
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Biocytogen

Targeted Models for Each Stage of Drug Discovery

RenMab™ mice contain the entire human immunoglobulin variable domain, which streamlines discovery and eliminates the need for humanization. Our RenLite® model contains a fixed common light chain that eliminates chain mispairing during bispecific antibody development. Immunized RenMice undergo in vivo selection and affinity maturation to generate quality antibody hits.

Biocytogen

RenMice™: Powering Fully Human Antibody Discovery

RenMab™ mice contain the entire human immunoglobulin variable domain, which streamlines discovery and eliminates the need for humanization. Our RenLite® model contains a fixed common light chain that eliminates chain mispairing during bispecific antibody development. Immunized RenMice undergo in vivo selection and affinity maturation to generate quality antibody hits.

CRO Products and Services

Models & services to get you from target to therapeutic candidate

Animal & Cell Models (BIOMICE)

We offer the most comprehensive collection of humanized models to evaluate efficacy of human immunotherapies.

Gene Editing Services

From point mutation knock-in alleles to transgenics, we deliver quality custom animal and cell models.

Efficacy & Toxicity Services

Comprehensive preclinical PK/PD, in vivo, and in vitro evaluation of novel test articles.

Technology Platforms

Industry-leading technologies that accelerate drug discovery

Gene Editing Technology

From design to F1 in 5-7 months, our proprietary platform delivers quality models faster.

Bispecific ADC Platform

Antibodies derived from RenLite mice against 200+ TAA targets are available for BsADC generation.

Anti-GPCR Antibody Platform

KO RenMice provide a solution for challenging GPCR targets with complex multi-pass transmembrane structure.

Nanobody Platform

RenNano-derived antibodies can infiltrate tumor tissues, cross the blood-brain barrier, or be constructed into other therapies.

Step into our brand-new facility!

Why Waltham, MA? Because we want to get closer to our clients!

Our priority? Your project success. Every detail matters to us. Explore the next level of collaboration and excellence. Welcome to the future of innovation!

Biocytogen

Your Premier Partner for Drug Discovery

Powered by cutting-edge gene editing technologies and a state-of-the-art animal facility, Biocytogen offers solutions for preclinical antibody drug discovery and efficacy validation. Our CRO & vivarium sites in Boston and China have enabled global partnerships with numerous academic and industrial clients to accelerate basic and preclinical research.

Cutting Edge Technologies

Founded in 2009, our proprietary, efficient genetic engineering technologies have made us a global leader in animal and cell model generation. Development of our advanced chromosome engineering technology and high-throughput antibody discovery platform further expanded our capabilities for therapeutic antibody discovery using our fully human antibody mice.

With the largest catalog of humanized models available and an experienced in vivo pharmacology team, we have completed over 1,300 drug evaluation projects. Our fast turnaround times and dedication to superior customer service have set us apart. 

Whether you need gene editing, antibody discovery, or pharmacology services, our cutting-edge platforms provide fast and reliable solutions.

Biocytogen

Biocytogen provides hundreds of genetically modified off-the-shelf BIOMICE for basic and preclinical research. Our large collection of humanized immune-checkpoint, humanized cytokine/cytokine receptor, humanized TAA mice, and immunodeficient mice, which have been published in hundreds of studies, facilitate in vivo efficacy assessments of novel anti-human immunotherapies.

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