Transgenic Technology

Our innovative gene-editing technology increases gene-editing efficiency by 10 to 20 fold,
making our custom model development process faster and more affordable for your research.

The Difference Between Genome Editing Technology and Transgenic Technology

Both Genome editing technology and transgenic techniques can alter the genome of an organism so that the desirable trait can be inherited, but there is a big difference between the two. Genome editing is the targeted/locus specific manipulation of the genome of the organism itself by knocking out or replacing targeted genes which results in individuals with intentionally selected and desired traits, while transgenic technology introduces biologically nonexisting foreign genes randomly integrated into the genome of the original organisms in order to tailor the species with new traits.

Generation of animal lines through random integration, transgenesis, can lead to several confounding effects on gene expression, including multiple integrations per cell, the activation or disruption of endogenous genes at or near the site of integration, and unstable expression of the transgene due to epigenetic modifications. These, coupled with the constitutive and often high expression levels of the transgene, can lead to unpredictable cell behavior and irreproducible or hard to interpret results.

Targeted gene editing overcomes these limitations by introducing modifications at the endogenous locus of the gene (and only this site). Consequently, the effect of gain or loss of function can be studied in the specific genomic context. Although Biocytogen has the most advanced gene targeting technology and capacity, we still can meet some customers’ special needs for random insertion transgene requests.

Transgenic Technologies Available

Tol2 Transposon System:

The Tol2 transposon system allows insertion of transgene-mediated genes at the A/T rich region so that the expression of the transgene is more efficient.

BAC Transgenic:

BAC transgenic technology is  to add exogenous genes to the host species and was widely applied to many experimental organisms and economical organisms such as crops, livestock.

Engineered BAC Knockin

Available upon special request. Contact gene editing scientist to learn more today.

Mb-level chromosome engineering

Available upon special request. Contact gene editing scientist to learn more today.

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