Animal & Cell Models

We provide a number of genetically-modified animal models including humanized immune-checkpoint mouse models, humanized cytokines mice, and humanized cell lines for basic and preclinical research.

Developing a new drug for human use is a lengthy and costly process that takes an average of 10 years or more and costs approximately $2.6 billion. Yet, when one considers the number of people a successful drug can help, the return on investment can be astounding.

Before a drug goes to market, its efficacy, safety, and mechanism of action (MOA) must be thoroughly understood. Furthermore, it is critical that efficacy is established. In vivo animal models for research work to minimize adverse side effects and maximize therapeutic properties of a drug before it is taken to clinical trials. Biocytogen is a one-stop CRO specializing in immuno-oncology and autoimmune humanized animal models, which can help move projects from target to IND application.

Animal Models for Research

Although scientists have made significant technological advancements for in vitro models and methods, those applications are limited when it comes to human translational research. Moreover, ethical and safety concerns require that drugs be proven safe with certain levels of efficacy before they are approved for medical use. To profile drugs, toxicology and efficacy studies are primarily performed in animal models for research. As such, animal models are indispensable in preclinical profiling, especially in cancer research and drug development.

Anatomically and physiologically speaking, humans and animals are very similar as they share the same organs and organ systems that perform similar life functions. Particularly, rodents such as mice and rats are practical as animal models. 

Biocytogen, provides a number of genetically-modified animal models for basic and preclinical research, which includes syngeneic mouse models and xenografts. Syngeneic mouse tumor models are defined as mice inoculated with tumor cells that are from the same genetic background. Syngeneic mouse models come with an intact immune system, allowing them to be used for efficacy assessment and screening tools for immunotherapies. Our humanized immune checkpoint mouse models, engineered to express human forms of immune signaling molecules, are ideal for studying antibody activity on human cells.

In contrast to syngeneic models, xenograft models use cells from one species to transplant into another, often human cells into an immunodeficient mouse. Depending on whether the cells come from a patient or an established cell line, patient-derived xenografts (PDX) and cell-derived xenografts (CDX) can allow in vivo testing of anti-cancer treatments on human tumors. Through adoptive transfer of human-derived cells or tissue into the highly immune-deficient B-NDG™ mouse, human immune systems can be reconstituted and studied in vivo.  

Cell Line Engineering Services

Cell line engineering — also referred to as cell line editing — involves the genetic altering of cell lines to determine the effects of a specific alteration. In studying phenotypic changes of these cells, scientists can drive the discovery of new drugs and therapies for various types of cancer cells. Biocytogen has more than a decade of experience engineering a wide range of cell backgrounds, from HeLa, 293FT and HEK 293 to more challenging-to-confect cell lines such as fibroblasts, endothelium-derived, neuroblastoma-derived, bone-marrow-derived hepatocellular-carcinoma-derived cells, and hiPSC.

Biocytogen — A World Leader in Animal & Cell Line Engineering Services

Biocytogen has been serving customers, both in academia and industry, around the world for over a decade. With our commitment to quality in everything we do, we’ll work closely with you to deliver models and services that meet your precise specifications in a timely manner. We offer world-leading, cutting-edge technology platforms, superior service, a fast timeline, a large collection of animals for research and a 100 percent satisfaction guarantee.

Our facility in Haimen, China is AAALAC-accredited and can house up to 3,000,000 rodents, adhering to the humane treatment of research animals. Shipping is available to our customers worldwide. For more information about our products and services, contact us today.

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