Atopic Dermatitis Mouse Model Introduction
- Atopic dermatitis (AD) is a chronic skin disease that presents with itching, erythema and squamous lesions, and can be associated with cardiovascular disease, mental disorders (depression, anxiety, sleep disorders, etc.) and other diseases.
- Atopic dermatitis mouse models:
- Induced by enhanced skin sensitization using epithelial sensitive antigens, haptens, etc.
- Genetically engineered atopic dermatitis mouse model;
- Spontaneous atopic dermatitis mouse model.
- Biocytogen uses wild-type C57BL/6 mice and B-hIL4/hIL4RA double humanized mice on the C57BL/6 background to experimentally induce AD-like lesions via oxazolone (OXA) sensitization and continuous challenge. The resulting atopic dermatitis mouse model can be used for preclinical efficacy evaluation of therapeutic candidates.
Watch our December 2021 webinar: Investigating Inflammatory Disease using Humanized Cytokine Mice
