Publications using Off-the-shelf Models

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Targeting Mechanistic Target of Rapamycin Complex 1 Restricts Proinflammatory T Cell Differentiation and Ameliorates Takayasu Arteritis

Used in this study: Immunodeficient B-NDG Mice

A high-throughput single cell-based antibody discovery approach against the full-length SARS-CoV-2 spike protein suggests a lack of neutralizing antibodies targeting the highly conserved S2 domain

Chai M, Guo Y, Yang L, Li J, Liu S, Chen L, Shen Y, Yang Y, Wang Y, Xu L, Yu C. A high-throughput single cell-based antibody discovery approach against the full-length SARS-CoV-2 spike protein suggests a lack of neutralizing antibodies targeting the highly conserved S2 domain. Brief Bioinform. 2022 May 13;23(3):bbac070. doi: 10.1093/bib/bbac070. PMID: 35362510.

The establishment and application of CD3E humanized mice in immunotherapy

Zhang R, Zhang J, Zhou X, Zhao A, Yu C. The establishment and application of CD3E humanized mice in immunotherapy. Exp Anim. 2022 May 13. doi: 10.1538/expanim.22-0012. Epub ahead of print. PMID: 35570001.

Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment

Zejie Mei, Tao Yang, Ying Liu, Yuanyuan Gao, Zemin Hou, Qian Zhuang, Dongyin He, Xuebin Zhang, Qilong Tan, Xuyou Zhu, Yingyi Qin, Xi Chen, Chengdang Xu, Cuidong Bian, Xinan Wang, Chenyang Wang, Denglong Wu, Shengsong Huang, Zhenfei Li, Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment, Cell Reports Medicine, 2022, 100608, ISSN 2666-3791, https://doi.org/10.1016/j.xcrm.2022.100608.

Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity

Song, D., Liu, X., Dong, C. et al. Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity. Sci Rep 11, 22966 (2021). https://doi.org/10.1038/s41598-021-02449-y

BMI1 regulates multiple myeloma-associated macrophage’s pro-myeloma functions

Zhang, D., Huang, J., Wang, F. et al. BMI1 regulates multiple myeloma-associated macrophage’s pro-myeloma functions. Cell Death Dis 12, 495 (2021). https://doi.org/10.1038/s41419-021-03748-y

The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML

Qiao, X., Ma, J., Knight, T. et al. The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML. Blood Cancer J. 11, 111 (2021). https://doi.org/10.1038/s41408-021-00502-7

Natural small molecule triptonide inhibits lethal acute myeloid leukemia with FLT3-ITD mutation by targeting Hedgehog/FLT3 signaling

Xu, Y., Wang, P., Li, M. et al. Natural small molecule triptonide inhibits lethal acute myeloid leukemia with FLT3-ITD mutation by targeting Hedgehog/FLT3 signaling. Biomed Pharmacother. (2021). https://doi.org/10.1016/j.biopha.2020.111054

MUC1-Tn-targeting chimeric antigen receptor-modified Vγ9Vδ2 T cells with enhanced antigen-specific anti-tumor activity

Zhai, X., You, F., Xiang, S. et al. MUC1-Tn-targeting chimeric antigen receptor-modified Vγ9Vδ2 T cells with enhanced antigen-specific anti-tumor activity. Am J Cancer Res. (2021). PMID: 33520361

LunX-CAR T Cells as a Targeted Therapy for Non-Small Cell Lung Cancer

Hu, Z., Zheng, X., Jiao, D. et al. LunX-CAR T Cells as a Targeted Therapy for Non-Small Cell Lung Cancer. Mol Ther Oncolytics. (2020). https://doi.org/10.1016/j.omto.2020.04.008