Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Authors: Jang-June Park, Emily P. Thi, Victor H. Carpio, Yingzhi Bi, Andrew G. Cole, Bruce D. Dorsey, Kristi Fan, Troy Harasym, Christina L. Iott, Salam Kadhim, Jin Hyang Kim, Amy C. H. Lee, Duyan Nguyen, Bhavna S. Paratala, Ruiqing Qiu, Andre White, Damodharan Lakshminarasimhan, Christopher Leo, Robert K. Suto, Rene Rijnbrand, Sunny Tang, Michael J. Sofia & Chris B. Moore

Citation: Park, J.-J., Thi, E.P., Carpio, V.H. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. (2021). https://doi.org/10.1038/s41467-021-21410-1

Used in this study: double humanized B-hPD-1/hPD-L1 mice; humanized B-hPD-L1 MC38 cells