Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy
Wu, W., Zhou, Q., Masubuchi, T. et al. Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy. Cell. (2020). https://doi.org/10.1016/j.cell.2020.07.018
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GPS2 promotes erythroid differentiation by control of the stability of EKLF protein
Ma, W.-B., Wang, X.-H., Li, C.-Y. et al. GPS2 promotes erythroid differentiation by control of the stability of EKLF protein. Blood. (2020). https://doi.org/10.1182/blood.2019003867
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Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy
Li, W., Qiu, S., Chen, J. et al. Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy. Immunity. (2020). https://doi.org/10.1016/j.immuni.2020.07.011
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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
Wang, J., Li, Y., Wang, P. et al. Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis. Cell Stem Cell. (2020). https://doi.org/10.1016/j.stem.2020.04.001
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piRNA-30473 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in DLBCL
Han, H., Fan, G., Song, S. et al. piRNA-30473 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in DLBCL. Blood. (2021). https://doi.org/10.1182/blood.2019003764
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Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment
Zhou, C., Zhang, Y., Yan, R. et al. Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment. Cell Death Differ. (2021). https://doi.org/10.1038/s41418-020-00618-6
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An unexpected role for p53 in regulating cancer cell–intrinsic PD-1 by acetylation
Cao, Z., Kon, N., Liu, Y. et al. An unexpected role for p53 in regulating cancer cell–intrinsic PD-1 by acetylation. Sci Adv. (2021). DOI: 10.1126/sciadv.abf4148
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Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer
Wang, S., Qu, Y., Xia, P. et al. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Res. (2020). https://doi.org/10.1038/s41422-020-0312-y
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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
Park, J.-J., Thi, E.P., Carpio, V.H. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. (2021). https://doi.org/10.1038/s41467-021-21410-1
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Targeting macrophage checkpoint inhibitor SIRPα for anticancer therapy
Liu, J., Xavy, S., Mihardja, S. et al. Targeting macrophage checkpoint inhibitor SIRPα for anticancer therapy. JCI Insight. (2020). https://doi.org/10.1172/jci.insight.134728
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