Publications using Off-the-shelf Models

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Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion

Zhang, S., Wang, C., Ma, B. et al. Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion. Cell Rep. (2020). https://doi.org/10.1016/j.celrep.2020.107879

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival

Deng, L., Yao, P., Li, L. et al. p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nat Commun. (2020). https://doi.org/10.1038/s41467-020-15573-6

SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation

Zhou, Y., Fan, X., Jiao, T. et al. SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation. Acta Pharm Sin B. (2021). https://doi.org/10.1016/j.apsb.2020.06.016

Olaquindox-Induced Liver Damage Involved the Crosstalk of Oxidative Stress and p53 In Vivo and In Vitro

Li, D., Pei, X., Qin, X. et al. Olaquindox-Induced Liver Damage Involved the Crosstalk of Oxidative Stress and p53 In Vivo and In Vitro. Oxidative Medicine and Cellular Longevity. (2020). https://doi.org/10.1155/2020/8835207

Silencing of functional p53 attenuates NAFLD by promoting HMGB1-related autophagy induction

Zhang, X., Lin, Y., Lin, S. et al. Silencing of functional p53 attenuates NAFLD by promoting HMGB1-related autophagy induction. Hepatol Int. (2020). https://doi.org/10.1007/s12072-020-10068-4

Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE -/- mice

Chen, W., Zhang, X., Xu, M. et al. Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE -/- mice. Eur J Nutr. (2021). https://doi.org/10.1007/s00394-020-02362-6

Maintenance of AMPK activation by metformin is beneficial for suppressing the progress of diabetes-accelerated atherosclerosis via inhibition of vascular smooth muscle cells migration

Yan Y, Li T, Li Z, He M, Wang D, Xu Y, Yang X, Bai Y, Lao Y, Zhang Z, Wu W. Metformin Suppresses the Progress of Diabetes-Accelerated Atherosclerosis by Inhibition of Vascular Smooth Muscle Cell Migration Through AMPK-Pdlim5 Pathway. Front Cardiovasc Med. 2021 Jul 23;8:690627. doi: 10.3389/fcvm.2021.690627. PMID: 34368251; PMCID: PMC8342753.

APOE2 promotes the development and progression of subretinal neovascularization in age-related macular degeneration via MAPKs signaling pathway

Sun, Y., Song, R., Ai, Y. et al. APOE2 promotes the development and progression of subretinal neovascularization in age-related macular degeneration via MAPKs signaling pathway. Saudi J Biol Sci. (2020). https://doi.org/10.1016/j.sjbs.2020.06.037

A longitudinal 18F-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) study in apolipoprotein E (ApoE) knockout rats fed with a Western diet

Zhuang, X., Feng, Y., Li, J. et al. A longitudinal 18F-fluorodeoxyglucose (18F-FDG) and 18F-sodium fluoride (18F-NaF) positron emission tomography/computed tomography (PET/CT) study in apolipoprotein E (ApoE) knockout rats fed with a Western diet. Cardiovasc Diagn Ther. (2021). http://dx.doi.org/10.21037/cdt-20-609

Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging miR-93-5p to inhibit TGF-β signalling

Huang, W., Yang, Y., Wu, J. et al. Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging miR-93-5p to inhibit TGF-β signalling. Cell Death Differ. (2020). https://doi.org/10.1038/s41418-019-0455-x