Publications using Off-the-shelf Models

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Effective antitumor activity of 5T4-specific CAR-T cells against ovarian cancer cells in vitro and xenotransplanted tumors in vivo

Guo, C., Dong, E., Lai, Q. et al. Effective antitumor activity of 5T4-specific CAR-T cells against ovarian cancer cells in vitro and xenotransplanted tumors in vivo. MedComm. (2020). https://doi.org/10.1002/mco2.34

Promising xenograft animal model recapitulating the features of human pancreatic cancer

Miao, J.-X., Wang, J.-Y., Li, H.-Z. et al. Promising xenograft animal model recapitulating the features of human pancreatic cancer. World J Gastroenterol. (2020). https://dx.doi.org/10.3748/wjg.v26.i32.4802

Expression levels of a gene signature in hiPSC associated with lung adenocarcinoma stem cells and its capability in eliciting specific antitumor immune-response in a humanized mice model

Wang, J., Shao, L., Wu, L. et al. Expression levels of a gene signature in hiPSC associated with lung adenocarcinoma stem cells and its capability in eliciting specific antitumor immune-response in a humanized mice model. Thorac Cancer. (2020). https://doi.org/10.1111/1759-7714.13440

Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma

Chen, H.-D., Huang, C.-S., Xu, Q.-C. et al. Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma. Int J Biol Sci. (2020). doi:10.7150/ijbs.39779

Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription

Citation: Chen, Z., Xiang, L., Hu, Z. et al. Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription. Am J Cancer Res. (2021). PMID: 33520374

Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals

Dong, Y., Bai, J., Zhang, Y. et al. Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. J Leukoc Biol. (2020). https://doi.org/10.1002/JLB.1A0520-179R

Protease-activated receptor 2 stabilizes Bcl-xL and regulates EGFR–targeted therapy response in colorectal cancer

Li, W., Ma, Y., He, L. et al. Protease-activated receptor 2 stabilizes Bcl-xL and regulates EGFR–targeted therapy response in colorectal cancer. Cancer Letters. (2021). https://doi.org/10.1016/j.canlet.2021.05.040

Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody

Zhang D, Jiang F, Zaynagetdinov R, Huang H, Sood VD, Wang H, Zhao X, Jenkins MH, Ji Q, Wang Y, Nannemann DP, Musil D, Wesolowski J, Paoletti A, Bartholomew T, Derner MG, An Q, Iffland C, Halle JP. Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Oncoimmunology. 2020 Apr 1;9(1):1744921. doi: 10.1080/2162402X.2020.1744921. PMID: 32313722; PMCID: PMC7153820.

Tislelizumab uniquely binds to the CC’ loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage

Hong, Y., Feng, Y., Sun, H. et al. Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage. FEBS Open Bio. (2021). https://doi.org/10.1002/2211-5463.13102

Oral uptake and persistence of the FnAb-8 protein characterized by in situ radio-labeling and PET/CT imaging

Wang, Q., Hai, W., Shi, S. et al. Oral uptake and persistence of the FnAb-8 protein characterized by in situ radio-labeling and PET/CT imaging. Asian Journal of Pharmaceutical Sciences. (2020). https://doi.org/10.1016/j.ajps.2020.03.002