Publications using Gene Editing Services or Custom Models

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Chitosan Hydrogel Enhances the Therapeutic Efficacy of Bone Marrow-Derived Mesenchymal Stem Cells for Myocardial Infarction by Alleviating Vascular Endothelial Cell Pyroptosis

Liu Y, Li P, Qiao C, Wu T, Sun X, Wen M, Zhang W. Chitosan Hydrogel Enhances the Therapeutic Efficacy of Bone Marrow-Derived Mesenchymal Stem Cells for Myocardial Infarction by Alleviating Vascular Endothelial Cell Pyroptosis. J Cardiovasc Pharmacol. 2020 Jan;75(1):75-83. doi: 10.1097/FJC.0000000000000760. PMID: 31663873; PMCID: PMC7668671.

Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

Wang, J., Li, Y., Wang, P. et al. Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis. Cell Stem Cell. (2020). https://doi.org/10.1016/j.stem.2020.04.001

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

Peng, J., Liu, Y., Umpierre, A.D. et al. Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice. Mol Brain. (2019). https://doi.org/10.1186/s13041-019-0492-x

NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival

Grun, D., Adhikary, G., Eckert, R.L. NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival. Oncogene. (2018). https://doi.org/10.1038/s41388-018-0290-4

CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy

Qin, R., Cao, S., Lyu, T. CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy. Cell Rep. (2017). https://doi.org/10.1016/j.celrep.2016.12.043

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

Wang, X., Chen, H., Tian, R. Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF. Nat Commun. (2017). doi: 10.1038/ncomms14091

Generation of Hutat2:Fc Knockin Primary Human Monocytes Using CRISPR/Cas9

Wang, B., Zuo, J., Kang, W. Generation of Hutat2:Fc Knockin Primary Human Monocytes Using CRISPR/Cas9. Mol Ther Nuc Acids. (2018). https://doi.org/10.1016/j.omtn.2018.01.012

KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility

Valero, M.S., Ramón-Gimenez, M., Lozano-Gerona, J. KCa3.1 Transgene Induction in Murine Intestinal Epithelium Causes Duodenal Chyme Accumulation and Impairs Duodenal Contractility. Int J Mol Sci. (2019). https://doi.org/10.3390/ijms20051193

IL-7/IL-7R signaling differentially affects effector CD4+ T cell subsets involved in experimental autoimmune encephalomyelitis

Arbelaez, C.A., Glatigny, S., Duhen, R. IL-7/IL-7R signaling differentially affects effector CD4+ T cell subsets involved in experimental autoimmune encephalomyelitis. J Immunol. (2015). doi:10.4049/jimmunol.1403135

A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses

Yang, X., Tian, T., Li, X. A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses. Mol Psychiatry. (2018). https://doi.org/10.1038/mp.2016.151