Publications using Gene Editing Services or Custom Models

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Liraglutide Attenuates Hepatic Ischemia-Reperfusion Injury by Modulating Macrophage Polarization

Li SL, Wang ZM, Xu C, Che FH, Hu XF, Cao R, Xie YN, Qiu Y, Shi HB, Liu B, Dai C, Yang J. Liraglutide Attenuates Hepatic Ischemia-Reperfusion Injury by Modulating Macrophage Polarization. Front Immunol. 2022 Apr 5;13:869050. doi: 10.3389/fimmu.2022.869050. PMID: 35450076; PMCID: PMC9016191.

GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils

Liu C, Zhou M, Jiang W, Ye S, Tian S, Jiang C, Hao K, Li H, Hu Q. GPR105-Targeted Therapy Promotes Gout Resolution as a Switch Between NETosis and Apoptosis of Neutrophils. Front Immunol. 2022 Mar 30;13:870183. doi: 10.3389/fimmu.2022.870183. PMID: 35432308; PMCID: PMC9005804.

Generation of an induced pluripotent stem cell line from a patient with Angelman syndrome carrying UBE3A mutation

Li S, Zhu Q, Cai Y, Yang Q. Generation of an induced pluripotent stem cell line from a patient with Angelman syndrome carrying UBE3A mutation. Stem Cell Res. 2022 Apr 25;62:102791. doi: 10.1016/j.scr.2022.102791. Epub ahead of print. PMID: 35489268.

N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system

Jiang F, Shen J, Cheng J, Wang X, Yang J, Li N, Gao N, Jin Q. N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system. Sci Adv. 2022 Apr 29;8(17):eabm2343. doi: 10.1126/sciadv.abm2343. Epub 2022 Apr 29. PMID: 35486720; PMCID: PMC9054023.

Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2

Xiong, X., Chen, S., Shen, J. et al. Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2. Sig Transduct Target Ther7, 99 (2022). https://doi.org/10.1038/s41392-022-00918-y

Auts2 deletion involves in DG hypoplasia and social recognition deficit: The developmental and neural circuit mechanisms

JUN LI, XIAOXUAN SUN, YANG YOU, QIONGWEI LI, CHENGWEN WEI, LINNAN ZHAO, MENGWEN SUN, HU MENG, TIAN, ZHANG, WEIHUA YUE ,LIFANG WANG, AND DAI ZHANG, SCIENCE ADVANCES, 2 Mar 2022, Vol 8, Issue 9, DOI: 10.1126/sciadv.abk1238

Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline

Weitzel, A. J., Grunwald, H.A., Weber, C. et al. Meiotic Cas9 Expression Mediates Gene Conversion in the Male and Female Mouse Germline. PLOS Biology. (2021). https://doi.org/10.1371/journal.pbio.3001478.

PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis

Yang, W., Guo, X., Tu, Z. et al. PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis. Protein Cell (2021). https://doi.org/10.1007/s13238-021-00888-x

IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy

Chen, T., Ding, X., Liao, Q. et al. IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy. J Immunother Cancer. (2021). http://dx.doi.org/10.1136/jitc-2020-001647

Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval

Shi MM, Fan KM, Qiao YN, Xu JH, Qiu LJ, Li X, Liu Y, Qian ZQ, Wei CL, Han J, Fan J, Tian YF, Ren W, Liu ZQ. Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval. Mol Psychiatry. 2020 May;25(5):977-992. doi: 10.1038/s41380-019-0435-z. Epub 2019 May 29. PMID: 31142818; PMCID: PMC7192851.