Basic Information
Strain Name
NOD.CB17-PrkdcscidIl2rgtm1Sirpatm1(SIRPA)/Bcgen
Common Name
B-NDG hSIRPA mice
Background
B-NDG
Catalog number
110604
Related Genes
SIRPα (signal regulatory protein alpha）
NCBI Gene ID
Description
Biocytogen developed the immunodeficient B-NDG hSIRPA mouse model. The targeting strategy used was that exon 2 of the mouse Sirpα gene, which encodes the extracellular domain, was replaced by human SIRPα in B-NDG mice. This mouse combines a highly immunodeficient B-NDG mouse background (completely lacking mature T, B and NK cells and is deficient in cytokine signaling) with the extracellular domain of the human SIRPα protein.
