Basic Information
Strain Name
NOD.CB17-PrkdcscidIl2rgtm1B2mtm2(B2M/HLA-A2.1)/Bcgen
Common Name
B-NDG HLA-A2.1 mice
Background
B-NDG
Catalog number
110599
Related Genes
HLA
Description
To achieve HLA-restricted human immune response, we independently created the highly immunodeficient NOD/SCID/IL2rg null strain (B-NDG) with homozygous expression of HLA class I heavy chain and lightchain (B-NDG HLA 2.1 mice). The murine B2m gene (Exon1 to Exon3) was replaced by the sequence encompassing the human B2M CDS and HLA-A*0201 gene. The HLA-expressing humanized mouse with functional HLA-restricted T cells and consistent representation of rare T-cell subsets overcomes a major constraint in human immunology, and serves as a useful model for investigating human immune responses against pathogens and for the development of therapeutic strategies against human diseases.
