Basic Information
Strain Name
NOD.CB17-PrkdcscidIl2rgtm1Il6tm1(IL6)/Bcgen
Common Name
B-NDG hIL6 mice
Background
B-NDG
Catalog number
110596
Related Genes
Il6 (interleukin 6）
NCBI Gene ID
Description
Biocytogen developed the highly immunodeficient B-NDG hIL6 mouse model, in which the targeting strategy was to replace the sequence encompassing the ORF of mouse Il6 with its human counterpart. This immunodeficient B-NDG model expresses human IL6 cytokine to improve engraftment and survival of human leukocytes, myeloid cells, and monocytes. B-NDG hIL6 mice will become a suitable animal model to investigate the role of the human immune system in xenograft studies.
