Basic Information
Strain Name
NOD.CB17-PrkdcscidIl2rgtm1B2mtm1Fcgrttm1(B2m)/Bcgen
Common Name
B-NDG B2m KO mice plus
Background
B-NDG
Catalog number
110601
Related Genes
B2m (beta-2 microglobulin) ; Fcgrt (Fc receptor, IgG, alpha chain transporter,as known as Fcrn)
Description
B-NDG B2m KO mice plus combines the severely immunodeficient B-NDG mouse background with the loss of the MHC class I molecule β2m, which does not show a difference in the metabolism of IgG drugs compared to wild-type mice. B-NDG B2m KO mice plus can be useful for studying the in vivo mechanism of xenograft versus host disease and for therapeutic drug efficacy evaluation.
