B-hAFP mice test 2

Basic Information

Common Name

B-hAFP mice test 2

Catalog Number

111644

Disease

Lewis lung carcinoma

Organism

Mouse

Strain

C57BL/6N–Afp^tm1(AFP)/Bcgen

Background

C57BL/6N

Related Genes

AFP (AFPD, FETA, HPAFP)

NCBI Gene ID

mRNA expression analysis: Species-specific CD3E protein expression analysis in wild-type and humanized B-hCD3E/h4-1BB/HLA-A2.1 mice. Splenocytes were isolated from wild-type C57BL/6 and B-hCD3E/h4-1BB/HLA-A2.1 mice, and analyzed by flow cytometry using species-specific anti-CD3E antibodies. Mouse CD3E was detected in wild-type mice, while human CD3E was detected in B-hCD3E/h4-1BB/HLA-A2.1 mice (CD3EH/H; 4-1BBH/H; HLA-A2.1H/+) and B-hCD3E/h4-1BB/HLA-A2.1 mice (CD3EH/H; 4-1BBH/H; HLA-A2.1H/H).

Species-specific HLA protein expression analysis in wild-type and humanized B-hCD3E/h4-1BB/HLA-A2.1 mice. Splenocytes were isolated from wild-type C57BL/6 and B-hCD3E/h4-1BB/HLA-A2.1 mice and analyzed by flow cytometry. Mouse H-2Db was detected in wild-type and B-hCD3E/h4-1BB/HLA-A2.1 mice (CD3EH/H; 4-1BBH/H; HLA-A2.1H/+). Human HLA-A2.1 was detected in B-hCD3E/h4-1BB/HLA-A2.1 mice (CD3EH/H; 4-1BBH/H; HLA-A2.1H/+) and B-hCD3E/h4-1BB/HLA-A2.1 mice (CD3EH/H; 4-1BBH/H; HLA-A2.1H/H).