Basic Information
Strain Name
C57BL/6-Pdcd1tm1(PDCD1) Cd274tm1(CD274) Tnfrsf18tm1(TNFRSF18)/Bcgen
Stock Number
131108
Common Name
B-hPD-1/hPD-L1/hGITR mice
Background
C57BL/6
Aliases
PDCD1 also known as PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1.
CD274 also known as B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1.
TNFRSF18 also known as AITR; GITR; CD357; GITR-D; ENERGEN
Target Strategy
Exon 2 of mouse Pdcd1 (which encodes the IgV domain) was replaced by human PDCD1 exon 2 in B-hPD-1/hPD-L1/hGITR mice. Exon 3 of mouse Cd274 (which encodes the IgV domain) was replaced by human CD274 exon 3 in B-hPD-L1/hPD-L1/hGITR mice. Exons 1-4 of mouse Tnfrsf18 (which encodes the extracellular domain) was replaced by human TNFRSF18 exons 1-4 in B-hPD-1/hPD-L1/hGITR mice.
