Basic Information
Strain Name
C57BL/6-Pdcd1tm1(PDCD1)Cd274tm1(CD274)CD40tm1(CD40)/Bcgen
Stock Number
131083
Common Name
B-hPD-1/hPD-L1/hCD40 mice
Background
C57BL/6
Related Genes
PD-1(Programmed death-1) ；CD274 (CD274 antigen) CD40 (CD40 antigen)
Target Strategy
The exon 2 of mouse PD-1 gene that encodes the extracellular domain was replaced by human PD-1 exon 2 in B-hPD-1/hPD-L1/hCD40 mice. The exon 3 of mouse pdl1 gene that encode the extracellular domain was replaced by human PD-L1 exon 3 in B-hPD-1/hPD-L1/hCD40 mice. The exon 2-7 of mouse tigit gene that encodes the extracellular domain was replaced by human CD40 exon 2-7 in B-hPD-1/hPD-L1/hCD40 mice.
NCBI Gene ID
