Basic Information
Strain Name
C57BL/6-Pdcd1tm1(PDCD1)Cd276tm1(CD276)/Bcgen
Stock Number
121152
Common Name
B-hPD-1/hB7-H3 mice
Background
C57BL/6
Related Genes
PD-1, PDCD1, 4Ig-B7-H3, B7-H3, B7H3, B7RP-2
Targeting Strategy
Exon 2 of the mouse Pd-1 gene (which encodes the extracellular domain) was replaced by human PD-1 exon 2 in B-hPD-1/hB7-H3 mice. Exons 3-4 of mouse Cd276 (which encodes the extracellular domain) was replaced by human CD276 exons 3-6 in B-hPD-1/hB7-H3 mice.
NCBI Gene ID
