Human Hematopoietic Cell Engraftment
Biocytogen’s severely immune-deficient B-NDG mice are an ideal model for the engraftment of human peripheral blood mononuclear cells (PBMCs) and human CD34+ hematopoietic stem cells (hHSC). These human immune cell engraftment models are powerful tools for examining the effects of immuno-oncology agents on human immune cells.
Human Tumor Cell Models
Biocytogen has also engrafted multiple cell line-derived xenograft (CDX) models in B-NDG mice, including human solid tumor and hematological tumor cell lines. We have generated CDX mouse models from cancers such as lung carcinoma, colorectal adenocarcinoma, colon carcinoma, breast cancer, pancreatic carcinoma, bladder carcinoma, glioblastoma, liver cancer, and various leukemia and lymphoma cell lines. Additionally, we can develop custom CDX mouse models for subcutaneous, orthotopic, or metastatic tumor models based on our customer’s requirements. We provide pharmacodynamic (PD) services for any of these CDX mouse models.
