AACR 2022: Humanized TROP2 Mice Provide a Preclinical Tool for the Evaluation of Therapeutic Drugs Targeting TROP2
Conclusions • We generated a mouse model expressing human TROP2 in place of the murine counterpart. • Human TROP2 expression was detected in homozygous BhTROP2…
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AACR 2022: Evaluating In Vivo Efficacy of Peptide Vaccines in Humanized B-HLA-A2.1 Mice
Conclusions Human B2M and HLA-A2.1 proteins were detected in homozygous humanized B-HLA-A2.1 mice, while mouse B2M and H-2Kb/H-2Db proteins were not detected. Introduction of hB2M-HLA-A2.1-H-2D…
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AACR 2022: Identifying New Therapeutic Antibodies Using Knockout Mice Expressing Human Immunoglobulin Variable Domain Genes
Conclusions In conclusion, the RenMice™ HiTS (Hyperimmune Target Specific) Platform enables accelerated identification of fully human antibodies with increased diversity of antibody paratopes and species…
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AACR 2022: Evaluating In Vivo Efficacy of Anti-VSIG4 Antibodies in Humanized B-hVSIG4 Mice
Conclusions We have generated a humanized mouse model expressing human VSIG4 in place of the murine counterpart. mRNA and protein expression of human VSIG4 indicates…
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AACR 2022: Evaluation of Therapeutic Drug Candidates Using a Novel Humanized B-hCSF1/hCSF1R
Conclusions Protein expression analysis by ELISA and flow cytometry: Murine CSF1 protein was detected in splenocytes isolated from wild-type C57BL/6 (+/+) mice, while human CSF1…
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AACR 2022: B-hIL12A/hIL12B/hIL12RB1/hIL12RB2: A Novel Animal Model for Generation of IL12 Therapies
Conclusions We successfully established a novel B-hIL12A/IL12B/IL12RB1/IL12RB2 multi-gene humanized mice that expresses human IL12A, IL12B, IL12RB1 and IL12RB2, whose CD4+ T cells specifically respond to…
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AACR 2022: YH008, a PD-1-CD40 Bispecific Antibody, Inhibits Tumor Growth In Vivo Through PD-1-Dependent Activation of CD40 Signaling
Conclusions The PD1-CD40 human bispecific antibody YH008 demonstrates: • Activation of CD40 signaling in a PD1-dependent manner in vivo. • Superior in vivo efficacy against…
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AACR 2022: Developing a Translational Tool for GLP-1-Based Therapeutic Agonists in Humanized GLP1R Mice
mRNA and protein expression analysis: Human GLP1R mRNA was exclusively detected in the lung of homozygous B-hGLP1R mice compared to wild-type mice by RT-PCR. Similarly,…
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AACR 2022: Evaluating Delivery of TFR1-targeting Therapies to the CNS in a Novel Humanized TFR1 Mouse Model
Conclusions Human TFR1 expression was analyzed in homozygous B-hTFR1 mice by flow cytometry and RT-PCR. When compared with wild type mice, there were no abnormalities…
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AACR 2021: Humanized IL17A/IL17F mouse model provides a preclinical tool for the evaluation of therapeutic drugs targeting to IL-17 pathway
Expression of the proinflammatory cytokine interleukin 17 (IL-17) by activated CD4+ T cells has been associated with autoimmune disease pathogenesis. Biocytogen generated a double humanized…
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