Leptin is a peptide hormone secreted by adipocytes and is mainly expressed by white adipose tissue. Additionally, leptin is also found to be expressed in the myocardium, skeletal muscle, placenta, lung, breast epithelium and gastric mucosa. Functionally, leptin can inhibit appetite, increase energy expenditure, and inhibit fat synthesis to promote its decomposition. Insulin can promote the secretion of leptin, which in turn plays a negative feedback regulatory role in the synthesis and secretion of insulin.
B-ob/ob mice (Product number 110172) were generated by knocking out exons 2 and 3 of the leptin gene using EGE technology. B-ob/ob mice are a powerful model for studying modulators of obesity and hyperglycemia.
