Rheumatoid Arthritis Model Introduction
- Rheumatoid Arthritis (RA) is among the most common autoimmune diseases. Clinical symptoms of RA include generalized joint swelling, pain and motion disorder. Severe cases of RA lead to disability, as evidenced by hyperplastic synovitis, cartilage injury and bone structure destruction.
- Collagen-induced arthritis (CIA) is a common experimental rheumatoid arthritis mouse model induced by immunization with type II collagen (CII), the major constituent protein of articular cartilage. Animal models immunized with CII develop autoimmune polyarthritis, which shares several clinical and histological features with rheumatoid arthritis.
At Biocytogen, we have established stable rheumatoid arthritis mouse models in different strains of mice (C57BL/6, DBA), which can be used for pharmacodynamic evaluation of RA-related drugs.
