Basic Information
Strain Name
NOD.CB17-PrkdcscidIl2rgtm1/Bcgen
Common name
B-NDG mice; B: Biocytogen; N: NOD background; D: DNAPK (Prkdc) null; G: IL2rg knockout
Catalog number
110586
Genotype
Male: Prkdc (-/-), IL2rg (X-/Y); Female: Prkdc (-/-), IL2rg (X-/X-)
Description
The immunodeficient B-NDG mouse model (NOD.CB17-PrkdcscidIl2rgtm1/Bcgen) was independently designed and generated by Biocytogen. B-NDG mice are generated by deleting the IL2rg gene from NOD-scid mice with severe immunodeficiency phenotype. Lacking mature T cells, B cells, functional NK cells and displaying cytokine signaling deficiencies, this mouse model has the highest degree of immunodeficiency and thus is most suitable for engraftment and growth of human hematopoietic stem cells (HSCs), peripheral blood mononuclear cells (PBMCs) and human tumor cells or tissues.
