Basic Information
Strain Name
C57BL/6-Egfrtm2(EGFR)/Bcgen
Common Name
B-hEGFR mice
Background
C57BL/6
Catalog Number
120771
NCBI Gene ID
Related Genes
EGFR, ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor
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Gene Targeting Strategy
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Gene targeting strategy for B-hEGFR mice. The exons 2-17 of mouse Egfr gene that encode the extracellular domain were replaced by human EGFR exons 2-17 in B-hEGFR mice.
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mRNA expression analysis
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Strain specific analysis of EGFR gene expression in wild type (WT) mice and B-hEGFR mice by RT-PCR. Mouse Egfr mRNA was detectable only in liver of WT mice (+/+). Human EGFR mRNA was detectable only in homozygous B-hEGFR mice (H/H) but not in WT mice (+/+).
