Basic Information
Strain Name
SD-Tp53tm1/Bcgen
Stock Number
210507
Common Name
B-p53 KO rats
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Tp53 (tumor protein p53)
Species
Sprague Dawley
Appearance
White
Genotypes
Tp53KO (mut/mut); Tp53KO (wt/mut)
NCBI Gene ID
Description
Tp53tm1/Bcgen rats are a useful model for studying tumor formation, screening in vivo carcinogenicity, and examining the efficacy of therapeutic agents.
The Tp53 KO rat model was developed using targeted TALEN technology in the Sprague-Dawley strain. This model possesses a 12 bp deletion and 2 bp insertion within Exon 2 of Tp53 on chromosome 10. This strain was maintained by mating heterozygous females with homozygous males on a Sprague-Dawley genetic background.
