AACR 2022: Generation of TCR-like fully human antibodies against HLA-antigen-peptide complexes using HLA transgenic RenMice

AACR 2022: Generation of TCR-like fully human antibodies against HLA-antigen-peptide complexes using HLA transgenic RenMice

Conclusions

• We describe an HLA transgenic mouse that acquires fully human TCR mimic antibodies through a proprietary immunization procedure.
• Beacon on-chips screening and high-throughput binding validation accelerate antibody discovery.
• Diversified antibody sequences ensure the screening of antibodies with high specificity and high affinity.